The plot of Mafia III remained unchanged in the Final Edition and introduces a new hero and setting similar to the previous installments. The main character returns from military service, this time after the Vietnam War. When Lincoln Clay returns to his hometown of New Bordeaux (modeled on New Orleans) in 1968, he has only one goal: to take revenge on those who led to the extermination of his loved ones. This includes, in particular, the person of Sal Marcano, donor to the influential Italian mafia responsible for the massacre.

The authors slightly improved the graphics, but the whole thing does not differ much from the premiere version of the game from 2016. The highlight of this release is the ability to download the digital content pack for free. It consists of three additional story campaigns: Gas Up !, Unfinished Business and the Sign of the Times. Each of them presents a different adventure of Lincoln Clay, and the expected attractions include a fight with a corrupt sheriff and a dark cult. In addition, the set includes DLC with new weapons and outfits.